@@ 22,14 22,14 @@ or downloaded as
 
 These programs use data from
 [ChEMBL
-28](ftp://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/releases/chembl_28/). The programs which use fingerprints expect them to be in the file
+28](https://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/releases/chembl_28/). The programs which use fingerprints expect them to be in the file
 <q>chembl\_28.fpb</q> in the current directory. The programs which use
 the [SQLite](https://sqlite.org/index.html) database expect to find it
 in <q>chembl\_28\_sqlite.db</q> in the current directory. You can also
 configure them to use a different location, typically through the
 command-line arguments ``--fingerprints`` and ``--sqlite``.
 
-### &#8226; To get&nbsp;`chembl_28.fpb`:
+### &#8226; How to get&nbsp;`chembl_28.fpb`:
 
 To get <q>chembl_28.fpb</q>, download
 [chembl_28.fpb.gz](/datasets/chembl28.fpb.gz) and uncompress it.  Here

          
@@ 48,14 48,14 @@ and other legal details for redistributi
 While chemfp supports gzip-FPB files, it is typically significantly
 faster to work with uncompressed files.
 
-### &#8226; To get&nbsp;`chembl_28.db`:
+### &#8226; How to get&nbsp;`chembl_28.db`:
 
 To get <q>chembl\_28.db</q>, download the
-[ChEMBL 28 SQLite distribution](ftp://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/releases/chembl_28/chembl_28_sqlite.tar.gz),
+[ChEMBL 28 SQLite distribution](https://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/releases/chembl_28/chembl_28_sqlite.tar.gz),
 un-compress and un-tar it, and move the file <q>chembl\_28.db</q> to
 your working directory. Here is one way to do it: 
 
-<pre style="margin-left: 2em"><code>wget ftp://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/releases/chembl_28/chembl_28_sqlite.tar.gz
+<pre style="margin-left: 2em"><code>wget https://ftp.ebi.ac.uk/pub/databases/chembl/ChEMBLdb/releases/chembl_28/chembl_28_sqlite.tar.gz
 tar xf chembl_28_sqlite.tar.gz
 mv chembl_28/chembl_28_sqlite/chembl_28.db .
 </code></pre>